Contraceptive injections

Illustration of contraceptive injectionContraceptive injections contain a progestogen hormone which is similar to the natural progesterone produced by the ovaries.

There are three types of injection. DepoProvera and Sayana Press protect you from pregnancy for 13 weeks. Noristerat protects you for eight weeks; it’s not commonly used in the UK.

Your Guide to Contraceptive Injections (PDF)

How effective any contraceptive is depends on how old you are, how often you have sex and whether you follow the instructions.


If 100 sexually active women don’t use any contraception, 80 to 90 will get pregnant in a year.


If the injection is always used perfectly, according to instructions, it’s over 99% effective. This means that fewer than one injection-user in 100 will get pregnant in one year.


If the injection is not always used according to instructions, about six in 100 injection-users will get pregnant in one year.


It’s important to have your next injection at the right time. If you miss, or are late, having the next injection you may no longer be protected against pregnancy.


The injection is a method of long-acting reversible contraception (LARC). LARC is very effective because while it’s being used you don’t have to remember to take or use contraception.

The main way they work is to stop your ovaries releasing an egg each month (ovulation). They also:

  • thicken the mucus from your cervix (entrance to the womb), making it difficult for sperm to move through it and reach an egg
  • make the lining of your uterus (womb) thinner so it’s less likely to accept a fertilised egg.

You can go to a contraception or sexual health clinic or to the doctor or nurse at a general practice. All treatment is free and confidential (see How to get help with your sexual health).

It’s most likely that you’ll be offered Depo-Provera or Sayana Press. Your doctor or nurse can discuss with you which contraceptive injection is the most suitable for you.

You’ll need to have an injection once every 13 weeks if you have Depo-Provera or Sayana Press or once every eight weeks for Noristerat.


Depo-Provera and Noristerat are injected into a muscle, usually in your buttocks. Depo-Provera can also sometimes be given in the arm. Noristerat is a thicker solution so you may find the injection is slightly more painful when it’s given.


Sayana Press is injected beneath the skin at the front of the thigh or abdomen. It’s possible for you to be taught how to inject Sayana Press yourself at home but not all clinics and general practices currently offer this option.


You don’t need to have a vaginal examination or a cervical screening test to have a contraceptive injection.

Most women can have a contraceptive injection. Your doctor or nurse will need to ask you about your own and your family’s medical history to make sure a contraceptive injection is suitable. Do mention any illness or operations you’ve had. 

Some of the conditions which may mean you shouldn't use the injection are:

  • you think you might already be pregnant
  • you don't want your periods to change
  • you want a baby within the next year.

You have now or had in the past:

  • breast cancer
  • unexplained vaginal bleeding (for example, bleeding between periods or after sex)
  • arterial disease or history of serious heart disease or stroke
  • severe disease of the liver 
  • risk factors for osteoporosis (thinning of the bones) (see below, Can I use the injection if I'm at risk of osteoporosis?).
  • You don’t have to think about contraception for as long as the injection lasts.
  • It’s not affected by other medicines.
  • It may reduce heavy painful periods and help with premenstrual symptoms for some people.
  • You can use it if you’re breastfeeding.
  • It’s a good method if you can’t use estrogens, like those in the combined pill, contraceptive patch and contraceptive vaginal ring. 
  • Your periods may change in a way that’s not acceptable to you (see below, Will a contraceptive injection affect my periods?).
  • Irregular bleeding may continue for some months after you stop the injections. 
  • Some people may put on weight when they use Depo-Provera or Sayana Press (see below, Will my weight be affected by a contraceptive injection?). 
  • The injection works for 13 or eight weeks, depending on which type you have. It can’t be removed from your body, so if you have any side effects, you have to be prepared for them to continue during this time and for some time afterwards.
  • There can be a delay of up to one year before the return of your periods and fertility after stopping the injection.
  • Contraceptive injections don’t protect you against sexually transmitted infections, so you may have to use condoms as well. 
  • Some people experience side effects such as spotty skin, hair loss, decreased libido, mood swings and headaches.
  • Using Depo-Provera or Sayana Press may affect your bones (see below, How does the contraceptive injection affect my bones?)
  • Research about the risk of breast cancer and hormonal contraception is complex and contradictory. Research suggests that people who use hormonal contraception, such as the injection, may have a small increase in the risk of being diagnosed with breast cancer compared to those who don’t use hormonal contraception. 
  • You can have an allergic reaction to the injection, but this is rare.
  • As with any injection, there’s a small risk of a reaction at the spot the injection is given, which may cause irritation, swelling or a scar.

Your doctor or nurse should discuss all risks and benefits with you.

  • Using Depo-Provera or Sayana Press affects your natural estrogen levels, and may cause thinning of the bones. This isn’t normally a problem for most injection-users as the bone replaces itself when you stop the injection and it doesn’t appear to cause any long-term problems.
  • Thinning of the bones may be more of a problem if you already have risk factors for osteoporosis (see below, Can I use a contraceptive injection if I’m at risk of osteoporosis?). 
  • If you’re under 18 years old you may use Depo-Provera or Sayana Press, but only after careful evaluation by a doctor or nurse. This is because young people under 18 are still making bone.

If you have risk factors for osteoporosis (thinning of the bones) it’s normally advisable to use another method of contraception. Your doctor or nurse will talk to you about this. These factors include:

  • a lack of estrogen due to menopause or early menopause (before 45 years)
  • a lack of estrogen due to missing periods for six months or more, as a result of over-exercising, extreme dieting or eating disorders
  • smoking
  • heavy drinking
  • long-term use of steroids
  • a close family history of osteoporosis
  • certain medical conditions affecting the liver, thyroid and digestive system
  • being underweight.

You can help to make your bones healthier by doing regular weight-bearing exercise such as running and walking, eating a healthy diet with enough calcium and vitamin D, and cutting down on drinking alcohol and smoking.


The National Osteoporosis Society website can give you more information.

A bone scan before starting a contraceptive injection isn’t usually recommended. It may be useful for some people – usually those who’ve been identified as having risk factors for osteoporosis.

Your periods will probably change.

  • Most often, periods will stop completely.
  • Some women will have irregular periods or spotting (bleeding between periods).
  • Some injection users will have periods that last longer and are heavier.

These changes may be a nuisance but they’re not harmful.


If you do have prolonged bleeding it may be possible for the doctor or nurse to give you some additional hormone or medicine that can help control the bleeding. They may also check that the bleeding is not due to other causes, such as an infection.

Depo-Provera and Sayana Press are associated with an increase in weight in some people. If you’re under 18 years old and overweight before starting Depo-Provera or Sayana Press you may be more likely to gain weight with use.

You can start a contraceptive injection any time in your menstrual cycle if it’s certain that you’re not pregnant. If you start the injection during the first five days of your period you’ll be protected against pregnancy immediately. If you start it on any other day you won’t be protected for the first seven days, so you’ll need to use additional contraception, such as condoms, or avoid sex, during this time.

The injection can be started any time after giving birth. If you start the injection before three weeks (21 days) you’ll be protected against pregnancy immediately. If it’s started later than day 21 you’ll need to use an additional method of contraception, such as condoms, or avoid sex, for seven days. When using the injection within six weeks of giving birth you may be more likely to have heavy and irregular bleeding. The injection can be used safely if you’re breastfeeding.

The injection can be started immediately after an abortion or miscarriage and you’ll be protected against pregnancy straight away. If you start the injection more than five days after a miscarriage or abortion then follow the advice in When can I start using a contraceptive injection? below.

While the injection is working nothing will make it less effective.

The contraceptive injection isn't affected by:

  • prescribed medicines, including antibiotics
  • any medicines which you buy over the counter at a pharmacy
  • diarrhoea
  • vomiting.

It’s important to have your next injection at the right time – every 13 weeks for Depo-Provera and Sayana Press or every eight weeks for Noristerat. If you miss or are late having your next injection it may mean that you’re no longer protected against pregnancy.

Contraceptive injections are highly effective. If you’ve had your injection on time, it’s very unlikely that you’ll become pregnant. If you think that you might be pregnant then do a pregnancy test or speak to your doctor or nurse as soon as possible. Using the contraceptive injection doesn’t affect a pregnancy test. If you do get pregnant while you’re using the injection, there’s no evidence that it’ll harm the baby.

You can continue to use the injection until you're 50 years old, as long as there are no medical reasons not to and you're not at risk of osteoporosis (see How does a contraceptive injection affect my bones?). If you use the injection for a long time you should expect to have your risk factors for osteoporosis re-assessed every two years. The doctor or nurse may ask you about your lifestyle and discuss whether it'd be more suitable for you to use a different method of contraception.

If you want to stop a contraceptive injection, all you need to do is not have your next injection. Your periods and fertility may take a while to return to normal after you stop using the injection. However, it’s possible to get pregnant before your first period after stopping the injection. If you don’t wish to get pregnant then you should use another method of contraception from the day that your injection would’ve been due. If you have sex without using another method of contraception you may want to consider using emergency contraception.

 

If you want to try for a baby, start prepregnancy care such as taking folic acid and stopping smoking. You can ask your doctor or nurse for further advice.

 

No. It’s not necessary to stop a contraceptive injection if you’re having an operation. However, it’s always recommended that you tell the doctor that you’re using a contraceptive injection.

You only need to go to the clinic or your general practice when your injection is due. If you have any problems or want to ask any questions between injections, you should contact your doctor or nurse.


If you’ve been given a supply of Sayana Press to inject at home you’ll need to see a doctor or nurse at least once a year.

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This website can only give you general information about contraception. The information is based on evidence-guided research from the World Health Organization and The Faculty of Sexual and Reproductive Healthcare of the Royal College of Obstetricians and Gynaecologists. All methods of contraception come with a Patient Information Leaflet which provides detailed information about the method.

Remember – contact your doctor, practice nurse or a contraception clinic if you are worried or unsure about anything.

INFORMATION LAST UPDATED MAY 2017. NEXT PLANNED REVIEW 2020.